Technical Specifications: Diamine Oxidase (DAO)
Diamine Oxidase (DAO)
Diamine Oxidase (DAO) is a highly specialized oxidative enzyme responsible for the metabolic breakdown of dietary histamine and other biogenic amines within the digestive tract. It plays a foundational role in maintaining healthy systemic histamine balance, supporting normal gastrointestinal comfort, and preventing food-induced histamine sensitivity reactions.
Biological Origin & Source
Highly purified from premium porcine kidney extract, select plant-derived active matrices, or advanced microbial fermentation technologies. Carefully stabilized.
Key Product Characteristics
- ✔ Copper-containing amine oxidase, active in intestinal pH levels, and optimized for enteric-coated micro-granulation.
Functional & Nutritional Value Propositions
Primary Bio-Function
Catalyzes the oxidative deamination of exogenous histamine and related biogenic amines, transforming them into inactive metabolites within the intestinal lumen.
Digestive & Metabolic Wellness
Safely degrades excess histamine originating from aged, fermented, or histamine-rich foods, reducing digestive discomfort, bloating, and cramps.
Applications & Blends
Supports mucosal barrier health, promotes gastrointestinal comfort, and helps alleviate diet-induced digestive sensitivities in premium supplement blends.
Mechanism of Action (MOA)
- Histamine Accumulation: Dietary histamine from foods or fermentation enters the small intestine.
- Enzyme Activation: Exogenous Diamine Oxidase (DAO) mixes with the chyme, remaining active under physiological intestinal conditions.
- Oxidative Deamination: The Cu2+-catalyzed DAO enzyme binds to histamine, breaking its primary amine group via oxidation.
- Metabolite Neutralization: Histamine is converted into imidazole acetaldehyde, hydrogen peroxide, and ammonia.
- Systemic Protection: Lowers the influx of dietary histamine across the intestinal wall, preventing flushing and cramps.
Technical Specification Sheet
| Parameter | Standard Requirement / Value |
|---|---|
| Physical Appearance | White to creamish colored powder |
| Standard Enzyme Activity | High-potency standardized histamine-degrading activity |
| Activity Customization | Available as per customer requirement standards: FIP / USP / IP / BP / EP |
| Packaging Options | 1 kg, 5 kg, and 25 kg standard packing (Custom options on request) |
| Storage Protocols | Store in a cool and dry place; avoid direct sunlight |
Partner With Us for Nutraceutical Ingredients
Get in touch to receive trial samples, customized bulk quotes, and custom assay formulations.